Ans :-
• Define :- It is defined as the use of chemical compounds in the treatment of cancer and Infections diseases , so as to destroy the microorganisms without damaging the host tissues.
Example:- penicillin, tetracycline
• classification:-
1) Effective Against Gram Positive Bacteria :-
A) used for systemic infections :- penicillin
B) used topically:- bacitracin
2) effective against gram negative bacteria :-
A) used for systemic infections:- streptomycin, kanamycin
B) used locally in intestinal infections:- paromomycin
3) effective against both gram positive and gram negative bacteria:-
A) used for systemic infections:- ampicillin, ampicillin
B) used topically:- neomycin
4) effective against gram positive and gram negative bacteria, rickettsiae :- tetracycline, chloramphenicol
5) effective against acid fast bacilli:- rifamcin, streptomycin.
- Based On Side Of Action antibiotics cam be classified as :-
1) inhibitors of cell wall synthethesis :- penicillin
2) inhibitors of cell membrane function :- polymixin
3) inhibitors of protein synthesis:- tetracycline
4) inhibitors of nucleic acid synthesis / function:- rifamcin
5) inhibitors of metabolism :- sulpha drugs
OR ;
1) Effective against gram positive bacteria:- penicillin
2) effective against gram negative bacteria:- streptomycin
3) effective against both gram positive and gram negative bacteria:- tetracycline
4) effective topically:- polymixin
• Drug combination is used in treatment of tuberculosis:-
1) resistance to anti - TB Drugs Is developed quickly of used as a single drug .
2) combination therapy reduces bacterial load effectively and quickly.
3) combination therapy gives synergistic Effects.
4) side effects are lesser with the combination tham with single drug used in high dose.
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