Q. What are opioid analgesic ? Give example, write Pharmacological action of morphine.
Ans :-
• Define :- These are the Pharmacological agents, which when administered, relieve severe degrees of pain associated with burn , partitions , fractures , traumas , tumors , malignancy etc .
• Example:- morphine, codeine , thebaine , papavarine
• Pharmacological Action Of Morphine:-
1) CNS :-
On CNS morphine has shows biphasic action -
A) CNS Depressant
B) CNS stimulant
A) CNS Depressant:-
-Relieve All Types of pain .
-Respiratory centre depress by reducing tidal volume and respiratory rate .
- sedative - morphine shows calmly effect at higher dose it induces sleep and may causes comma.
- cough centre depress.
- vasomotar centre depress.
B) CNS stimulant:-
- Nausea and vomiting occurs as a side effect .
- they stimulant vegal centre.
2) ANS :-
They Causes Mile Hyperglycemia due to stimulation of sympathetic nerves
3) CVS :-
- morphine causes vasodilation and fall in Blood pressure due to release of histamine.
- it has a depressive action of vasomotar centres .
- direct action of decreasing blood vessels tone.
4) GIT :-
They Causes constriction of sphincter muscle which leads to decrease peristaltic movement and stagenation ( stable) imtentinal containt.
5) Smooth Muscle :-
Morphine increases the tone of all type of smooth muscle.
---------------------------------------------------------------------
ONLY FOR EDITOR